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Despite earlier reports of similar cases in history, it was Von Recklinghausen who was credited with first describing the condition we now know as neurofibromatosis type 1 (NF1) in 1882. NF1 is one of the most common autosomal dominant diseases, and affects approximately 1/2500–3000 individuals. An affected parent therefore has a 50% chance of passing it on to their children, but spontaneous mutations are possible even without a family history.

Chronic urticaria (CU) is a common, yet often misunderstood, dermatological condition with significant physical symptoms and psychological consequences. While the condition’s cutaneous manifestations are well recognized, its broader impact on patients’ quality of life, emotional well-being, and daily functioning is frequently underestimated.

During the peak of the COVID-19 lockdowns, dermatologists noticed something unusual: their waiting lists grew longer, not shorter. However, patients weren’t necessarily coming in for cosmetic concerns, they were desperate for relief from flare-ups of psoriasis, eczema and hives. Across the globe, skin diseases spiked along with emotional distress, validating the suspicion that stress doesn’t just live in the mind, it can also leave its mark on the skin.